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Biola Javierre

Group Leader

​Born in 1983 in Huesca (Spain), Biola studied Biology and Biochemistry at the University of Navarra (2006) and received her PhD in Molecular Biology (Epigenetics) from the Autonomous University of Madrid in 2011, where she worked under the supervision of Dr.  Manel Esteller and Dr. Esteban Ballestar at the CNIO.  She performed her postdoctoral training in Chromatin Dynamics (Peter Fraser Laboratory) in Cambridge (UK) from 2012 to 2017. Since March 2018, Biola is Junior PI at the Josep Carreras Reseach Center (IJC), first as Ramon y Cajal Fellow, and then as Junior PI La Caixa. In addition, Biola is part of the Bioinfo4Women Program at the Barcelona Supercomputing Center. In 2019, UNESCO and L’Oréal Women in Science Foundation recognised Biola as one out of the fifteen most promising young women scientists worldwide. Biola loves running although she has not time because of her little trouble makers.

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Interests

Current Team

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François Serra

Postdoctoral Researcher

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Teresa Robert 

Postdoctoral Researcher

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Lucía Álvarez

Postdoctoral Researcher

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Andrea Nieto-Aliseda

PhD Student

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Nicolás Byrne

PhD Student

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Ainhoa

Undergraduate Student

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Lucía Fanlo

Postdoctoral Researcher

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Maria Rigau

Postdoctoral Researcher

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Paulal López

PhD Student

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Álvaro Alcalde

PhD Student

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Galina

PhD Student

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Ainoa Planas

Postodoctoral Researcher

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Laureano Tomás

Postodoctoral Researcher

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Blanca Valero

PhD Student

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Raúl de Haro

PhD Student

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Arnau

Undergraduate Student

video

3. Non-coding determinants

Most of genetic determinants  associated with  complex diseases lie in non-coding regions, frequently at enhancers, and potentially exert their roles by altering the regulation of the target genes. However, these non-coding determinants remain unexplored because the vast majority of regulatory elements that control transcriptional activity of each gene in each cell type are unknown. Motivated by this limitation, we aim to use conformational methods to provide fundamental insights about the role of the non-coding genome in disease development.

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1. Hematopoiesis

All blood cells originate from hematopoietic stem cells, which are the apex of a differentiation cascade of progenitor cell types that give rise to billions of newly differentiated cells every day. Hematopoiesis is essential for the immune response, and its alteration can give rise to the development of cancer, immunodeficiency, allergy and autoimmunity. Despite its clinical relevance, hematopoiesis is not completely understood. We aim to apply integrative omics approach to better understand this physiological process.

 

Células madre embrionarias

2. Blood cancer

Chromatin interactions are crucial for cellular health due to their main role in genome expression regulation and errors in these interactions give rise to the development of a broad range of diseases including blood cancer. The investigation of these altered 3D structures can help us to improve our knowledge of the tumour process, providing new opportunities for the development of novel treatment approaches and diagnostic strategies.

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News

 

Happy Holidays from the JavierreLab! 🎄

December 2024

 

Today, we gathered for our unofficial Christmas dinner to celebrate the year gone by 🥳🍽

Here’s to another exciting year ahead, filled with groundbreaking science and collaboration! 🧬🎉

Christmas dinner

Team

Dedication. Expertise. Passion.

Current Team

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Alumni

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Current Team

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